Published: 08 May, 2023 | Volume 8 - Issue 1 | Pages: 004-013
Figure 3:
The SARS-CoV-2 interaction with ACE2 receptors would generate an imbalance of the Renin-Angiotensin and Bradykinin systems, producing a dysregulation of microcirculatory blood flow with a predominance of vasodilation with increased flow. The increase in microcirculatory flow produces a shear force on the capillary endothelium which, together with hypoxia, are strong stimuli of intussusceptive Angiogenesis responsible for the pattern of capillary recruitment. Hypoxia could be interpreted as an increase in the intrapulmonary shunt due to capillary recruitment/impaired hypoxic vasoconstrictor reflex and, in turn, stimulation of greater capillary recruitment. All these mechanisms together would result in a CAPILLARY RECRUITMENT Pattern that manifests as Increased Capillary Density in sublingual Microcirculation with SDF (Sidestream Dark Field) and Increased PPI.
Read Full Article HTML DOI: 10.29328/journal.jcicm.1001043 Cite this Article Read Full Article PDF
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