Abstract

Case Report

Novel Complication of Nusinersen Treatment: Hyponatremia

Yasemin Coban*

Published: 15 October, 2018 | Volume 3 - Issue 1 | Pages: 020-022

There are variations in therapeutic regimens of different liver diseases. The accurate diagnosis ensNusinersen treatment is a novel therapy for spinal muscular atrophy (SMA) type 1; consequently, the adverse reactions of the therapy, have not been well known, yet. The present study is a case report that declares a hyponatremia development after the nursinersen therapy. Since the therapy is quite new one and has limited practice, we hope that this rare complication will contribute to the scientific literature.

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References

  1. Biogen Inc. SPINRAZA (nusinersen) injection, for intrathecal use: US prescribing information. 2016; Ref.: https://goo.gl/DjKjoi
  2. Spinraza (nusinersen) Prescribing Information. Cambridge, MA: Biogen, 2017;
  3. Farrar MA, Park SB, Vucic S, Carey KA, Turner BJ, et al. Emerging therapies and challenges in spinal muscular atrophy. Ann Neurol. 2017; 81: 355–368. Ref.: https://goo.gl/rewjnT
  4. Claborn MK, Stevens DL, Walker CK, Gildon B. Nusinersen in the Treatment of Spinal Muscular Atrophy. Methods Mol Biol. 2018; 1828: 69-76. Ref.: https://goo.gl/esiVFr
  5. Ottesen EW. ISS-N1 makes the first FDA-approved drug for spinal muscular atrophy. Transl Neurosci. 2017; 8: 1–6. Ref.: https://goo.gl/thWsps
  6. Hoy SM. Nusinersen: first global approval. Drugs2017; 77: 473-479. Ref.: https://goo.gl/kZD3Cu
  7. Safety Team Leader Review. NDA 209531. Spinraza (nusinersen). Benefit-Risk Summary and Assessment. Center for Drug Evaluatıon And Research. Reference ID: 4028770.
  8. Jones DP. Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Hyponatremia. Pediatr Rev 2018; 39: 27-35. Ref.: https://goo.gl/VPgG1i

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